Optimization of Periodontal Disease Treatment Tactics in Patients With Chronic Hepatitis C After Achieving a Sustained Virological Response

Авторы

  • Ugiloy Makhmudova Автор

DOI:

https://doi.org/10.5281/zenodo.19970942

Ключевые слова:

chronic hepatitis C (CHC), direct-acting antivirals (DAAs), sustained virological response (SVR), hepatitis C virus (HCV), periodontal diseases, dental rehabilitation.

Аннотация

The article examines the problem of dental rehabilitation in patients who have achieved recovery from chronic
hepatitis C (CHC) following treatment with direct-acting antivirals (DAAs). Despite viral elimination and the achievement
of a sustained virological response (SVR), pathological changes in periodontal tissues may persist. A research design
is proposed to develop a comprehensive treatment algorithm that considers local immune status and functional hepatic
reserve.

Биография автора

  • Ugiloy Makhmudova

    Assistant Professor, Department of Orthopedic Dentistry,
    Samarkand State Medical University, Samarkand, Uzbekistan

Библиографические ссылки

1. World Health Organization. Global report on health data systems and capacity for viral hepatitis: goals for 2030.

Geneva: WHO; 2024.

2. Nagao Y., Kawahara K., Kawahara M. Impact of systemic inflammation on oral health in patients with chronic hepatitis

C after viral eradication by direct-acting antivirals. J Clin Med. 2022;11(14):4052.

3. Gigliotti J., Perillo L., Castiglia G., et al. Periodontal health and hepatitis C virus: a systematic review and meta-analysis

of the post-DAA era. J Periodontol. 2024;95(3):215-228.

4. Carrozzo M., Francia S. Oral manifestations of hepatitis C virus infection: an update. Oral Dis. 2023;29(Suppl 1):12-25.

5. Makhmudova U.B., Samatov A.A. Specifics of dental status in patients with chronic viral hepatitis C in the Samarkand

region. Journal of Hepato-Gastroenterology Research. 2025;6(2):45-51.

6. Shoukat S., Ahmed R., Khan M. Pro-inflammatory cytokine profiles in oral fluid as predictors of periodontal destruction

in post-HCV patients. Int J Dent Res. 2024;12(1):88-94.

7. Sutton A.J., Edmunds W.J., Gill O.N. Long-term outcomes and “immunological scarring” following successful DAA

therapy for hepatitis C. Lancet Gastroenterol Hepatol. 2023;8(5):441-453.

8. Borgia G., Gentile I. Direct-acting antivirals and extrahepatic manifestations: a new paradigm in HCV management.

World J Hepatol. 2024;16(4):112-120.

9. Lalla E., Papapanou P.N. Diabetes, hepatitis, and periodontal disease: the common inflammatory link. Periodontol

2000. 2023;91(1):135-152.

10. Zhamoityn A., Sadykova G. Evaluation of liver fibrosis using FibroScan in patients with periodontal disease: a

cross-sectional study. Central Asian J Med. 2025;9(1):30-38.

11. Gomez R., Martinez M. The role of secretor IgA and lysozyme in the oral defense of patients after viral hepatitis treatment.

Oral Health Prev Dent. 2025;23(2):155-163.

12. Porphyromonas gingivalis and the systemic inflammatory burden: a focus on hepatobiliary patients. J Dent Res.

2024;103(6):541-550.

13. Bedossa P. Liver fibrosis and the METAVIR score: clinical implications for multidisciplinary care. Clin Liver Dis.

2023;27(2):201-215.

14. Ismoilov S.I., et al. Epidemiological features of parenteral hepatitis in Uzbekistan: current trends and challenges.

Uzbek Med J. 2024;5(3):10-18.

15. GraphPad Software. Statistical analysis of clinical data in periodontal research. 10th ed. San Diego; 2024.

Опубликован

2026-04-27

Как цитировать

Optimization of Periodontal Disease Treatment Tactics in Patients With Chronic Hepatitis C After Achieving a Sustained Virological Response. (2026). MAKTABGACHA VA MAKTAB TA’LIMI JURNALI, 4(4). https://doi.org/10.5281/zenodo.19970942